The Effect of Hydroxychloroquine Treatment in Hashimoto's Thyroiditis

• Status: Completed
• Trial end date: 2013-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Hashimoto's thyroiditis is an autoimmune thyroid disease, which induced chronic inflammation of thyroid gland and destroys thyroid tissue.

Hydroxychloroquine is used as disease modifying anti-rheumatic drug (DMARD) for treatment of several autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis(RA) for more than one century.

The purpose of this study is to evaluate whether hydroxychloroquine is effective in treatment of Hashimoto's thyroiditis.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Taiwan University Hospital
• Treatments: Hydroxychloroquine

Criteria

Inclusion Criteria:

• Hashimoto's thyroiditis

• Euthyroid state (free T4 and thyroid-stimulating hormone level within normal limit)

• Never receive immunomodulators or immunosuppressants

Exclusion Criteria:

• Planned pregnant or already pregnant women

• Renal insufficiency

• Hepatic insufficiency

• Anemia

• Agranulocytosis

• Thrombocytopenia

• Glucose-6-phosphate dehydrogenase deficiency

• Porphyria cutaneous tarda

• Allergy to 4-aminoquinolone