Standard treatment for vitiligo often has unsatisfactory outcomes. With a new understanding
of pathogenesis, novel drugs have been introduced which have shown to be effective in
small-scale studies. Tofacitinib, a Janus kinase(JAK) inhibitor-2 has shown promising results
in the treatment of vitiligo. However, randomized controlled studies are required to confirm
these observations and identify the patients most likely to benefit from JAK-2 inhibition.
This open-labeled randomized clinical trial will be conducted at the department of
dermatology and venereology of US Bangla Medical College & Hospital in Dhaka for 6 months
duration from June 2021 to November 2021 to Vitiligo patients attending in the aforementioned
department will be approached for inclusion in the study. Finally, 80 patients who will
fulfill the inclusion and exclusion criteria will be included. All patients will be informed
about the nature of the study and the written consent will be taken in the consent form with
the assurance that their information will be made confidential. Baseline information such as
gender, age, disease history, and drugs used prior will be collected. All patients will
undergo baseline laboratory evaluation which will be repeated at 6weeks and 12weeks. Before
the beginning of treatment, digital images of the cutaneous lesions will be taken which will
be compared with the ones taken at 6weeks and the end of 12weeks follow up. The participants
will undergo randomization into 1:1 ratio into two equal groups. Group A will receive oral
Tofacitinib and Group B will receive topical 0.1%Mometasone furoate. All the participants
will receive allotted intervention for 12weeks. The patient will be followed up at 6 weeks
and end of 12 weeks. The primary outcome of the study will be the improvement of the Vitiligo
Area Scoring Index (VASI) score at 6 and12 weeks in all groups. Secondary outcomes will
include improvement in Vitiligo European Task Force (VETF) scoring. The data will be
systematically described and summarized and presented through descriptive statistics and
finally will be analyzed by the statistical program Statistical Package for Social Science
(SPSS) version 23.0(Chicago, Illinois, USA). The relevant statistical test will be used
during the analysis. In all cases, the significance level will set p <0.05. Ethical clearance
of the study will be obtained from the ethical review committee (ERC) of the study place.