Objectives:
Primary Objective:
To determine whether the addition of low dose methadone to morphine(in the methadone group)
has a lower dose escalation index as compared to the morphine alone(in the morphine group) at
Day 15 (+/- 3 days)
Secondary Objectives:
To determine whether individuals on the methadone arm have lower pain intensity than the
morphine alone arm as demonstrated by a decrease in two points from baseline (+/- 3 days) in
their ESAS score at Day 15 (+/- 3 days).
To determine whether the methadone group of experiences fewer opioid induced neurotoxic side
effects (including sedation, myoclonus, hallucinations, hyperalgesia and confusion) as
compared to the morphine alone group at Day 15 (+/- 3 days).