Role of Glucagon-Like Peptide-1 in Postprandial Hypoglycemia
Status:
Completed
Trial end date:
2014-12-01
Target enrollment:
Participant gender:
Summary
It has been proposed that the rapid gastric emptying of carbohydrate containing fluids into
the intestine causes hyperglycemia followed by reactive hypoglycemia. The investigators have
shown that glucagon-like peptide-1 (GLP-1) secretion in response to a glucose load is
increased in children with Post-prandial hypoglycemia (PPH). This is a proof of concept study
to investigate the causative role of GLP-1 in the pathophysiology of PPH after fundoplication
by evaluating the effects of GLP-1 receptor antagonism on metabolic variables after a mixed
meal.
Hypothesis: In children with post-prandial hypoglycemia after fundoplication, antagonism of
the GLP-1 receptor by exendin-(9-39) will elevate nadir blood glucose levels after a meal
challenge and prevent post-prandial hypoglycemia.