Role of AT1-receptor Blockers in Insulin-induced Vasodilation.

• Status: Unknown status
• Trial end date: 2009-07-01
• Target enrollment: 0
• Participant gender: All

Summary

In this study we hypothesize that blocking the angiotensin II AT1-receptor improves the insulin-induced microvascular dilatation. Objectives: 1. Does blockade of the angiotensin II AT1-receptor improve the insulin-induced microvascular effects in hypertensive patients. 2. Does blockade of the angiotensin II AT1-receptor impair the insulin-induced microvascular effects in normotensive control subjects?

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Maastricht University Medical Center
• Treatments: Angiotensin II; Angiotensinogen; Felodipine; Insulin; Irbesartan

Criteria

Inclusion Criteria:

hypertensive subjects:

1. 18-60 years

2. Caucasian

3. untreated hypertension >140/90mmHg.

normotensive subjects:

1. 18-60 years

2. Caucasian

3. Blood pressure <140/90 mmHg.

Exclusion Criteria:

1. Obesity (BMI>27kg/m2)

2. Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure)

3. Impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA

4. Smoking

5. Alcohol use >4U/day

6. Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs)

7. Pregnancy

8. Wearing contact lenses