Revisiting the Mechanism of the Anti-inflammatory Effect of Colchicine
Status:
Recruiting
Trial end date:
2021-04-01
Target enrollment:
Participant gender:
Summary
We are doing this research study to better understand the mechanism of action of colchicine,
a drug commonly prescribed for gout. Precisely, we aim to evaluate the effect of colchicine
on a specific protein (GDF15) blood levels at different timepoints after its administration.
This research study will compare GDF15 blood levels after the administration of colchicine or
placebo. The placebo looks exactly like colchicine but contains no active drug. During this
study, participants may get a placebo instead of colchicine. Placebos are used in research
studies to see if the results are due to the study drug or due to other reasons.
Phase:
Phase 1
Details
Lead Sponsor:
Brigham and Women's Hospital
Collaborators:
Harvard Medical School Harvard Medical School (HMS and HSDM)