Reversing Ticagrelor's Effects With Fresh Platelets
Status:
Completed
Trial end date:
2016-06-01
Target enrollment:
Participant gender:
Summary
Acute coronary syndrome (ACS) patients treated with antiplatelet drugs who require coronary
artery bypass grafting (CABG) surgery have to wait 5-7 days for the effects of the drugs to
wean off. This treatment-devoid period leaves the patient vulnerable, therefore any means to
shorten this period could be useful. The present study aims to investigate the possibility of
reversing the antiplatelet effects of ticagrelor with the help of fresh donor platelets.
Fresh platelets will be added to blood samples of treated patients in varying concentrations
at specific timepoints to determine the time and amount of fresh platelets needed to
normalize platelet reactivity in the treated samples.