Reversal of Neuromuscular Blockade and Perioperative Arrhythmias
Status:
Completed
Trial end date:
2019-11-01
Target enrollment:
Participant gender:
Summary
Patients scheduled for elective abdominopelvic laparoscopic surgery under general anesthesia
were included. Rocuronium was used for the neuromuscular blockade (NMB) and the level of NMB
was monitored with train-of-four (TOF) measurements. The participants from whom informed
consent had been received were allocated to two groups according to the agent used for
reversal of NMB, sugammadex, or neostigmine. The ECG recordings of the subjects were followed
with a rhythm Holter device throughout the procedure until the postoperative 12th hour.
Additionally, preoperative and immediate postoperative 12-lead ECGs were evaluated for
corrected QT calculations and QT dispersion. Proarrhythmogenicity was assessed with QT
related measurements. The documented arrhythmic events on the Holter monitoring were
designated as clinical end-points.