Pharmacokinetics Study on Nevirapine Resistance in Tanzania
Status:
Completed
Trial end date:
2010-06-01
Target enrollment:
Participant gender:
Summary
Primary
- pharmacokinetics of single dose nevirapine
- the effect of single dose carbamazepine on the pk of single dose nevirapine
- resistance against nevirapine before and after.
- follow-up on HIV status newborns
- relation between nevirapine levels in cord blood and plasma
Secondary
* safety of single dose nevirapine and nevirapine/carbamazepine
Hypothesis:
Single dose carbamazepine decreases development of resistance to nevirapine in HIV positive
pregnant Tanzanian women by decreasing nevirapine half-life.