Overview PeriOperative ISchemic Evaluation-3 Trial Status: Active, not recruiting Trial end date: 2022-12-01 Target enrollment: Participant gender: Summary This study is a multicentre, international, randomized controlled trial of tranexamic acid (TXA) versus placebo and, using a partial factorial design, of a perioperative hypotension-avoidance versus hypertension-avoidance strategy. Phase: Phase 3 Details Lead Sponsor: Population Health Research InstituteTreatments: Tranexamic Acid