Nitrofurantoin and Urinary Tract Infections (UTIs)

• Status: Terminated
• Trial end date: 2009-05-01
• Target enrollment: 0
• Participant gender: Female

Summary

Urinary tract infection (UTI) is the most common complication after surgery for prolapse or urinary incontinence. UTIs are painful and have the potential to turn into kidney infections. We are asking women who self-catheterize after surgery to try either an antibiotic or a placebo pill so we can see if we can prevent UTIs without causing side effects.

This study will not require any additional visits or blood draws. You will be asked to answer some questions, keep a brief diary of your experience, and immediately report any symptoms of a UTI to your doctor.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Pittsburgh
• Treatments: Nitrofurantoin; Tin Fluorides

Criteria

Inclusion Criteria:

• Women who fail a post-operative voiding trial and are willing to learn clean intermittent self-catheterization (CISC) prior to discharge from the hospital

Exclusion Criteria:

• Known drug allergy to nitrofurantoin

• A history of renal insufficiency

• Renal transplant

• Renal nephropathy

• A recent history of more than 3 Urinary Tract Infections (UTIs) per year

• Known immunocompromised condition (organ transplant, chemotherapy for cancer or arthritis, autoimmune diseases (lupus etc)).