Microneedle Pretreatment as a Strategy to Improve the Effectiveness of Topical Anesthetics Formulations

• Status: Completed
• Trial end date: 2020-01-30
• Target enrollment: 0
• Participant gender: Male

Summary

A randomized, crossover, double-blind, two-sessions clinical trial with 30 male volunteers was performed to access pain of local anesthesia after using a topical anesthetic associated or not with prior application of microneedles to the palatal mucosa region

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Campinas, Brazil
• Collaborator: Texas Tech University
• Treatments: Anesthetics; Anesthetics, Local; Epinephrine; Lidocaine

Criteria

Inclusion Criteria:

• Healthy male

Exclusion Criteria:

• Volunteers were free from cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal and haematological diseases, psychiatric disorders, smokers or alcoholic.