Lactated Ringer Versus Albumin in Early Sepsis Therapy
Status:
Completed
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
The use of albumin in critical ill patients is a matter of controversy. A large randomized
controlled trial reported that albumin was as safe and effective as crystalloid solution for
fluid replacement in intensive care unit, although the last one was less expensive. In
Surviving Sepsis Campaign International Guidelines there are no preference for crystalloids
over colloids. But recently, a retrospective analysis of patients with severe sepsis from
SAFE study reported that the use of albumin in these patients would be superior, regarding
reduction of mortality. The aim of this study is determine whether the use of albumin improve
clinical outcomes in patients with severe sepsis or septic shock.