Is Aminophylline More Effective Than Neostigmine/Atropine Mixture in the Treatment of Post-dural Puncture Headache
Status:
Completed
Trial end date:
2020-01-01
Target enrollment:
Participant gender:
Summary
Objectives: To compare the safety and efficacy of IV aminophylline versus IV
neostigmine/atropine mixture in the treatment of post-dural puncture headache (PDPH).
Background: PDPH is the most frequent complication of procedures associated with dural
puncture for spinal anesthesia or following accidental dural puncture during epidural
anesthesia. Since invasive treatments have known complications, pharmacologic management may
be preferable.
Patients and Methods: This was a prospective, randomized, double-blind, phase four clinical
trial; carried out on 60 patients presented with PDPH at our hospital. Patients were randomly
allocated into two equal groups (30 patients each); group A, received IV aminophylline, and
group NA, received IV neostigmine/atropine mixture.