Growth Hormone and Chromosome 18q- and Abnormal Growth

• Status: Completed
• Trial end date: 2005-06-01
• Target enrollment: 0
• Participant gender: All

Summary

We, the investigators at the University of Texas Health Science Center at San Antonio, want to learn if height and IQ (intelligence quotient) scores are improved by growth hormone (GH) treatment in children with chromosome 18 deletions and abnormal growth. Data from a previous study showed that growth hormone improved height in all children with 18q- and growth hormone deficiency. In addition, most of the study participants on growth hormone treatment showed an increase in IQ scores.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: The University of Texas Health Science Center at San Antonio
• Collaborators: Genentech, Inc.; South Texas Veterans Health Care System
• Treatments: Clonidine; Hormones; Mitogens

Criteria

Inclusion Criteria:

• Diagnosis of chromosome 18 deletion (cytogenetics report)

• Children with abnormal growth but who are not classically growth hormone deficient

Exclusion Criteria:

• Children previously on growth hormone therapy