Glutamatergic Modulation to Facilitate the Behavioral Treatment of Cocaine Use Disorders
Status:
Recruiting
Trial end date:
2022-04-01
Target enrollment:
Participant gender:
Summary
Changes in the communication of glutamate from one brain structure to another are important
in the development of therapy for cocaine use disorders. Our preliminary investigations
suggest that drugs that affect glutamate exchange may be effective at promoting and
maintaining individuals' abstinence from cocaine. The purpose of this randomized,
double-blind, controlled trial is to test various glutamate modulators in conjunction with
motivational enhancement therapy (MET) and mindfulness based relapse prevention (MBRP) for
cocaine use disorders.