Functional dyspepsia is a common gastrointestinal disorder. Symptoms can include stomach pain
or discomfort, bloating, fullness after eating meals, and nausea. These symptoms often
interfere with school and work, and weight loss may occur due to dietary restrictions.
The hypothesis of this study was that antidepressant therapy is more effective than placebo
in relief of the symptoms of functional dyspepsia, adjusting for psychological and
psychiatric co-morbidity. The study also examined if antidepressant therapy reduces
disability and improves quality of life in functional dyspepsia.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
Mayo Clinic
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Treatments:
Amitriptyline Amitriptyline, perphenazine drug combination Citalopram Dexetimide