Filgrastim-Treated Donor Peripheral Stem Cell Transplantation in Treating Patients With Acute Leukemia

• Status: Completed
• Trial end date: 2002-10-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Transplanted peripheral stem cells can sometimes be rejected by the body's tissues. Treating donor peripheral stem cells with filgrastim may increase the number of donor white blood cells. This may help to decrease the rejection of the transplanted cells in patients receiving them as treatment for acute leukemia.

PURPOSE: Phase II trial to study the effectiveness of filgrastim-treated donor peripheral stem cells in treating patients with acute leukemia who are undergoing peripheral stem cell transplantation.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fred Hutchinson Cancer Research Center
• Collaborator: National Cancer Institute (NCI)
• Treatments: Cyclophosphamide; Methotrexate

Criteria

DISEASE CHARACTERISTICS:

• One of the following diagnoses:

• Primary acute leukemia beyond first remission

• High-risk acute myelogenous leukemia

• Acute lymphoblastic leukemia in first remission

• Must have HLA-matched donor identical for HLA-A, -B, and DRB1 alleles

• No HLA-matched identical sibling or haploidentical relative incompatible for 0 or 1 HLA-A, -B, or -DRB1 loci on the non-shared haplotype

• No leukoencephalopathy

PATIENT CHARACTERISTICS:

Age:

• 55 and under

Performance status:

• Not specified

Life expectancy:

• Not specified

Hematopoietic:

• Not specified

Hepatic:

• SGOT no greater than 2 times normal

• Hepatitis B surface antigen negative

• No prior hepatitis C

Renal:

• No impaired renal function

• Creatinine less than 2 times normal

Cardiovascular:

• No symptomatic cardiac disease

Pulmonary:

• No active pulmonary disease

• DLCO at least 60% predicted

Other:

• HIV negative

• No disease or other malignancy that severely limits life expectancy

• No severe or life-threatening infection within the past 2 weeks

• No history of septate fungal infection or disseminated candidiasis

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• No prior bone marrow or peripheral blood stem cell transplantation

Chemotherapy:

• Not specified

Endocrine therapy:

• Not specified

Radiotherapy:

• No prior radiotherapy greater than 3,000 cGy to whole brain

• No prior radiotherapy of 1,500 cGy to chest or abdomen

• At least 6 months since prior involved-field radiotherapy to chest or abdomen

Surgery:

• Not specified