FMT Capsules in Treatment of Patients With Insomnia Clinical Research
Status:
Recruiting
Trial end date:
2023-12-31
Target enrollment:
Participant gender:
Summary
Objective: To investigate whether Fecal Microbiota Transplantation(FMT) can improve sleep in
patients with insomnia, its effect on gut microbiota and its metabolites, and its effect on
inflammatory factors, neurotransmitters and sex hormones in peripheral blood. Methods: The
study needs to recruit 60 patients with insomnia and randomly divide them into FMT capsule
treatment group or Placebo treatment group. The patients were followed up before the
treatment and 4, 8, and 12 weeks after the treatment. The sleep status of the patients was
assessed by Pittsburgh sleep quality index-PSQI, and the changes of gut microbiota and its
metabolites were detected by Metagenomic sequencing and metabonomics analysis.The expression
of cytokines, sex hormones and neurotransmitters in peripheral blood were detected by Elisa.