Epidural Analgesia Use in Pancreatic Resections

• Status: Completed
• Trial end date: 2020-02-07
• Target enrollment: 0
• Participant gender: All

Summary

The rationale for this study is to investigate the benefits of epidural analgesia in pancreatic resections in a prospective, single blind, randomized control trial. This study will evaluate both short and long-term outcomes related to epidural analgesia, providing a longitudinal and comprehensive perspective to the advantages and disadvantages of this technique. The investigators hypothesize that the use of epidural analgesia reduces a patient's consumption of morphine or morphine-equivalent in the post-operative period following pancreatic resections.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Washington University School of Medicine
• Treatments: Bupivacaine

Criteria

Inclusion Criteria:

• Undergoing pancreatic resection.

• Age ≥18 years old.

• Able to understand and sign an Institutional Review Board (IRB)-approved informed consent form.

Exclusion Criteria:

• Indication for operative intervention being chronic pancreatitis.

• Currently on warfarin with an INR≥1.4 or clopidogrel that cannot be discontinued 7 days prior to surgery;

• Most recent INR prior to surgery >1.4

• Most recent platelet count prior to surgery <70,000/mcl

• Chronic opioid use as defined by use of more than 20mg oxycodone, or equivalent, daily.

• History of pre-existing neuropathic pain conditions.

• Not giving consent for study participation.

• Known medical history of significant psychiatric or cognitive impairment

• History of HIV, Hepatitis B, and/or Hepatitis C