Effect of Dietary Glycemic Index on Beta-cell Function
Status:
Completed
Trial end date:
2019-08-01
Target enrollment:
Participant gender:
Summary
The study will determine if increasing the highs and lows of blood glucose levels (glycemic
variability) impairs insulin secretion in people with impaired glucose tolerance and/or
impaired fasting glucose who are at risk for developing type 2 diabetes. Furthermore, the
study will determine whether changes in beta-cell function are associated with glycemic
variability and whether they are mediated by oxidative stress. To decrease or increase
glycemic variability the study will provide subjects with special diets containing either low
or high glycemic index foods respectively for 4 weeks. To determine if oxidative stress is a
mediator, subjects on the high glycemic index diet will take either placebo or the
anti-oxidant N-acetylcysteine. The study will address the hypothesis that increased glycemic
variability results in increased oxidative stress and thereby exacerbates beta-cell
dysfunction in individuals with impaired glucose tolerance and/or impaired fasting glucose.
The findings may have important implications for the development of effective strategies
aimed at the prevention and treatment of type 2 diabetes. In addition, understanding the
contribution of dietary glycemic index to beta-cell dysfunction in subjects with pre-diabetes
may have a significant public health impact, including changes to dietary counseling and
promotion of healthier eating patterns.
Phase:
N/A
Details
Lead Sponsor:
Seattle Institute for Biomedical and Clinical Research