Dose-Escalation Study of RRx-001 in Combination With Whole Brain Radiation in Subjects With Brain Metastases
Status:
Completed
Trial end date:
2020-11-12
Target enrollment:
Participant gender:
Summary
In this dose-escalation study, the safety and tolerability of escalating dose levels of
RRx-001 administered intravenously twice a week in subjects with brain metastases receiving
whole brain radiation therapy (WBRT) will be assessed. Once a maximum tolerated dose is
identified, further (up to approximately 30) participants will be recruited. The study will
use MRI to monitor changes in tumor blood flow associated with RRx-001.