Diclofenac add-on to Treatment as Usual for Suicidal Patients

• Status: Withdrawn
• Trial end date: 2011-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether diclofenac is effective in the treatment of depressed patients with a recent suicide attempt.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Region Skane
• Treatments: Diclofenac

Criteria

Inclusion Criteria:

• Depressive disorder

• Montgomery Asberg Rating Scale Score more than 20 p.

• Recent suicide attempt (Treated as inpatient due to a recent suicide attempt)

• Informed consent

• Competence to give informed consent

Exclusion Criteria:

• Pregnancy

• Breastfeeding

• Serious somatic disease e.g. serious heart, vascular, hepatic, kidney, pulmonary, intestinal, endocrine, haematological or neurological diseases

• Ongoing substance abuse

• Schizophrenia or other psychotic disorders

• Ongoing psychosis

• Risk factors for cardiovascular events

• Ulcer or gastrointestinal bleeding

• Ongoing Electroconvulsive therapy

• Previous allergic reaction to NSAID, acetylsalicylic acid, sulfonamides or the diclofenac or sugar pill content

• Galactose intolerance, lactase deficiency or glucose-galactose malabsorption

• Ongoing treatment with warfarin or other anticoagulants

• Ongoing treatment with ACE inhibitors or angiotensin II antagonists Ongoing treatment with drugs known to effect the immune system Ongoing treatment with rifampicin, carbamazepine or barbiturates