Dexmedetomidine for Reversal of Cocaine's Effects on the Heart
Status:
Completed
Trial end date:
2014-01-15
Target enrollment:
Participant gender:
Summary
This study will use myocardial contrast echocardiography performed during a continuous
intravenous infusion of Definity microbubbles (Perflutren lipid microbubbles) to determine if
dexmedetomidine (an intravenous central sympatholytic drug) can reverse all the
cardiovascular effects of low-dose intranasal cocaine-including vasoconstriction in the
coronary microcirculation-both in cocaine-naïve and non-treatment seeking cocaine-addicted
subjects.