Pre-clinic evidences showed that DEX produces antinociception by inhibiting the activation of
spinal microglia and astrocyte decreasing noxious stimuli evoked release of nociceptive
substances and further interrupting the spinal neuron-glia cross talk and regulating the
nociceptive transmission under chronic pain condition. in this study, the analgesic efficacy
of Dexmedetomidine was evaluated by a new non-invasive nociceptive index (qNOX). In this
study, Anagel6000 analgesia monitor was used to quantitatively compare the analgesic efficacy
of Dexmedetomidine compared with Midazolam.