Comparative Evaluation of Chlorhexidine, Metronidazole and Combination Gels on Gingivitis

• Status: Unknown status
• Trial end date: 2018-02-02
• Target enrollment: 0
• Participant gender: All

Summary

Patient presenting to the dental clinic with gingivitis and fulfilling the inclusion criteria will be included in the study after taking informed consent. Participants will be divided into three groups. Each group will be instructed to apply metronidazole gel, chlorhexidine gel or combination of metronidazole and chlorhexidine gel on the marginal gingiva. Measurement for the gingival index will be taken at baseline, at 2 weeks and at 4 weeks interval

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Aga Khan University
• Treatments: Chlorhexidine; Chlorhexidine gluconate; Metronidazole

Criteria

Inclusion Criteria:

• Patients having 20 or more healthy teeth

• Systematically healthy patient with no co-morbid

• Subjects with clinically confirmed gingivitis having positive bleeding gums on probing in every sextant

• Subjects having teeth without any clinical attachment loss

Exclusion criteria:

• Subjects with clinical attachment loss of greater than 2 mm on two sites

• Pregnant or lactating females

• Subjects with removal or fixed dental prosthesis

• History of surgical or nonsurgical periodontal therapy in the last 6 months

• Use of antibiotic in the last 30 days

• Habit of smoking or use of smokeless tobacco

• Allergic to Metronidazole or Chlorhexidine

• Presence of any craniofacial syndrome patients

• Patients on medications that have effects on gingival conditions (such as Nifedipine, Cyclosporine and Phenytoin etc.