alpha2-agonists like clonidine offer several useful effects that make these drugs an
interesting alternative to benzodiazepines for pharmacological premedication. We therefore
sought to determine the effect of pre-anesthetic medication with clonidine vs. midazolam in a
randomized, double-blind, placebo controlled study. Effects of pre-anesthetic medication were
assessed on (1) bispectral index (BIS),(2) sedation score and visual analog scales for
anxiety and pain, (3) neuropsychologic tests to assess cognitive function and (4) circulating
stress hormones.
Phase:
N/A
Details
Lead Sponsor:
University Hospital Schleswig-Holstein University of Schleswig-Holstein