Antibiotic Prophylaxis in High-Risk Arthroplasty Patients

• Status: Recruiting
• Trial end date: 2025-06-01
• Target enrollment: 0
• Participant gender: All

Summary

To determine the effectiveness of a 7-day course of an oral, prophylactic antibiotic on the incidence of periprosthetic joint infection and wound complications following primary total hip and knee arthroplasty in a high-risk patient population.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Iowa
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Cefadroxil; Cephalexin; Clindamycin; Doxycycline; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

Criteria

Inclusion Criteria:

• Undergoing elective, primary total hip or total knee arthroplasty

• Between the ages of 18-99

• Has one or more of the following high risk criteria: body mass index (BMI) greater than 35kg/m^2, diagnosis of diabetes, active tobacco user, chronic kidney disease (estimated glomerular filtration (eGFR) < 60 mL/min/1.73 m2), nasal colonization of MRSA and/or MSSA or autoimmune/inflammatory disease.

Exclusion Criteria:

• Younger than 18 years old

• Undergoing a revision hip or knee arthroplasty

• Will have a subsequent total joint arthroplasty performed within 12 weeks of study enrollment

• Patient is discharged the same day as primary THA or TKA

• History of clostridium difficile colitis

• Undergoing non-elective procedure

• Hemiarthroplasty

• Unicompartmental knee arthroplasty

• Simultaneous bilateral total hip or knee arthroplasty

• Pregnant

• Unable to provide written consent