Aflibercept and FOLFOX6 Treatment for Previously Untreated Stage IV Colorectal Cancer
Status:
Unknown status
Trial end date:
2019-12-31
Target enrollment:
Participant gender:
Summary
This phase II trial studies how well giving aflibercept together with combination
chemotherapy works in treating patients with previously untreated colon or rectal cancer that
is metastatic or locally advanced and cannot be removed by surgery. Aflibercept may stop the
growth of colon or rectal cancer by blocking blood flow to the tumor. Drugs used in
chemotherapy, such as leucovorin calcium, fluorouracil, and oxaliplatin, work in different
ways to stop the growth of tumor cells, either by killing the cells or by stopping them from
dividing. Giving aflibercept together with combination chemotherapy may kill more tumor cells