Administration of Fibrinogen Concentrate for Refractory Bleeding

• Status: Not yet recruiting
• Trial end date: 2023-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Platelet transfusions are widely employed to prevent or treat bleeding episodes in patients with thrombocytopenia. Patients with bone marrow failure secondary to haematological malignancy and chemotherapy frequently receive prophylactic platelet transfusion when platelet level reaches 10x109.L-1, to avoid spontaneous major bleeding. Due to immune or nonimmune factors, platelet refractoriness may be observed and is defined as a repeated suboptimal response to platelet transfusions with lower-than-expected post-transfusion count increments. The management of patients with alloimmunization is complex and prophylactic platelet support is no longer indicated. Therefore, platelet refractoriness remains a clinically challenging complication.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Institut de Cancérologie de la Loire

Criteria

Inclusion Criteria:

• Patient affiliated to a social security regimen or beneficiary of the same

• Signed written informed consent form

• Confirmed diagnosis of a hematological malignancy and undergoing intensive chemotherapy, autologous stem cell transplantation or allogeneic stem cell transplantation

• Grade ≥ II hemorrhagic symptoms according to WWorld Health Organization classification

• Failure or impossibility to use Human Leucocyte Antigen-matched platelet unit

• Body weight between 38 and 78 Kgs

• Transfusion refractoriness as defined by Corrected count increment ≤ 5 and platelet level < 20.109.L-1

Exclusion Criteria:

• Pregnant women

• Patient under guardianship or deprived of his liberty or any condition that may affect the patient's ability to understand and sign the informed consent

• Refusing participation

• Patient presenting non-malignant hematological disease

• Patient with high plasmatic concentration of fibrinogen (>5g/L)

• Patient who received fibrinogen within 20 days before inclusion

• Contra-indication to fibrinogen (fibrinogen concentrate) or any excipient (fibrinogen concentrate)

• Patient with disseminated intravascular coagulopathy

• Patient with thromboembolic history

• Patient who received L-Asparaginase or acquired hypofibrinogenemia following treatment by L-Asparaginase

• Patient with known risk of thrombophilia (deficiency for antithrombin 3, C protein or factor V)

• Patient with anti-thrombotic treatment (anti-platelet or anti-coagulant therapy) at the time of enrolment

• Elevated body temperature ≥ 38.5°C

• Hospital stay for invasive surgery

• Patient with acute myeloid leukemia during the induction phase of chemotherapy.