Acarbose an alphaglucosidase inhibitor changes in a complex way the transport, the digestion
and the place of glucose release and absorption. As a result the intestinal milieu, the
intestinal flora and the provision of enzymes in the lower small destine are changed. This
should modify immune response of intestinal wall on food and its proinflammatory effects. The
small intestine is the biggest immune organ of the organism. The postprandial glucose
increase could have a direct effect on low-grade inflammation. Toxic effects (glucotoxicity),
activation of the immune system and low grad inflammation could be reasons of developing
endothelial dysfunction and affect plaque stability. The activity of the lymphocyte immune
system in the intestine would be a further component, by which acarbose could take influence
on diabetogenesis and atherogenesis. The question of an enterovasal axis is one of the new
research concepts. As indicators of this axis considered: leucocytes, high sensitive
C-reactive protein, plasminogen activator inhibitor antigen and lymphocytes sub-populations.
The effect of acarbose on these parameters in the postprandial phase are not known yet.
Phase:
Phase 3
Details
Lead Sponsor:
GWT-TUD GmbH
Collaborators:
Diakonissen Krankenhaus Dresden, Germany Technische Universität Dresden University of Regensburg