A Study to Identify Biomarkers of Hypoglycaemia in Patients With Type 2 Diabetes
Status:
Completed
Trial end date:
2018-01-10
Target enrollment:
Participant gender:
Summary
Glucose is a sugar carried in the blood stream that body uses for energy. If someone has
diabetes, blood glucose level can be erratic, sometimes becoming very low this is called
Hypoglycaemia (or a "hypo"), and can happen when blood glucose levels drop below 4 mmol/l.
So far in order to prove that a hypo happened for a patient, blood glucose level can only be
measured at time of the hypo and not after it.
In this study we are trying to identify certain chemical substances (biomarkers) in diabetic
patients that may be measured in blood tests of the patient up to after 24 hours of the hypo
and if we could prove that a hypo has happened we could adjust tablets and or insulin dosage
in a way to prevent further hypos.
The study will be conducted in the Diabetes Centre in Hull Royal Infirmary and will involve
three visits to the diabetes centre. The study can finish in a week time after the first
visit.
Visit 1 is the screening visit to identify eligibility to take part in the study. Visit 2
insulin infusion will be given to make participants blood sugar level fall lower than normal
for a short time and corrected quickly afterward. This is a stress for participant's body and
should stimulate certain chemicals that we are trying to identify during hypo.
In Visit 3, the main purpose of this visit which is done 24 hours after insulin infusion is
to take a blood sample and check how participants is after visit 2.
We will recruit 25 Type 2 Diabetic patients and 25 none diabetics to compare both results.
Both groups should not have ischemic heart disease, underactive thyroid or seizures and on
stable dosage of medications.