A Study of the Use of Methotrexate in the Treatment of Chronic Idiopathic Urticaria

• Status: Terminated
• Trial end date: 2008-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether methotrexate produces significant improvement in chronic idiopathic urticaria, compared with placebo

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Barnsley Hospital
• Treatments: Methotrexate

Criteria

Inclusion Criteria:

• severe unremitting chronic idiopathic urticaria

• disease resistant to treatment with antihistamines

• aged 18 years or more

Exclusion Criteria:

• predominant physical urticaria

• urticarial vasculitis

• any contraindication to the use of methotrexate, eg. pregnancy / breast feeding, women wanting to conceive or man wanting to father a child within 12 months of entry, use of drugs which interact, underlying medical conditions

• use of immunosuppressant within 4 weeks of entry